MyBioSource.com's Anti-PIK3R1/p85 Alpha Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The Anti-PIK3R1/p85 Alpha Antibody was generated using PIK3R1 as the antigen and it reacts with Human.
Description
Binds to activated (phosphorylated) protein -Tyr kinases, through itsSH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis ininsulin-sensitive tissues. Plays an important role in signaling inresponse to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling